Acridinium compounds and a process of making the same



steer LOUIS BENDA, 0F MAINKUR. NEAR FRANKFURT-ON"TEE-MAIN. GERMANY, ASSIQNQEQ; TO LEOPOLD CASSELLA & CO. GEEELLSCHAFT MIT BESGHEANETER HA'ETUNG, 1i

CORPORATION OF GERMANY.

ACBIDINIUM COMPQUNDS AND A. IRQCESfi; 0h EEXAKING THE SAME.

memes.

No Drawing. Application filed July 14,

To all whom it may concern Be it known that I, LOUIS Bnnm, a subject of the Swiss Republic, residing at Mainkur, near Frankfort-on-the lliain, Germany, Bismarckstrasse 8, have invented new Aeridinium Compounds and a Process of Making the Same (for which I have made application in Germany, January 19, 1918), of which the following is a full description.

It has been found that by the action of tannic acid in the presence of acid-binding agents, on the readily soluble salts of 3.6- dianiino-10-alkylacridinium bases. insoluble and hitherto unknown compounds are obtained, which are of technical importance fast pigments. Asregards their adaptability for therapeutics they are exceptionally well suited as dusting powders for open wounds and especially for administration per os. Whilst the original materials. for instance the 3.G-diamino-lO-methylsci-idiniumchloride, known under the name of Trypafiavine, are of an exceedingly bitter taste, which according to L. Bends.(l3 45,1798/ 1912) can still be perceived in a dilution of 1 240000, the new products are perfectly tasteless, they also do not dye the mucous menr branes of the mouth and throat, as is the case with the compounds stated above. In the course of digestion they change by degrees into soluble bodies producing the desired ct fects.

IL'mampZe.-5 kilos 3.6-diamino-10-methyl- -acridiniumchloride (D. R. P. 243085) are dissolved in 200 liters water and mixed with a solution of 10 kilos tannic acid in 200 liters water and a 40 liters solution of acetate of soda, double normal.

Specification of Letters latent.

Patented hug". 20,, 1821. Serial lto. use.

which in cold water dissolves extremely dithcultly', whereas in hot water and alcohol clear orange coloured solution obtained.

In concentrated sulphuric acid the product dissolves nearly colourless. The solution is strongly green fluorescent.

If in the above example the 3.6-diamino- 10-n1ethylacridiniiimchloride is substituted by homologues and analogues, compounds similar properties are obtained.

Having now particularly described and ascertained the nature of my said invention and in. what manner the same is to be performed, I declare that what I claim is:

1. A process of preparing new sparingly soluble acridiniuni compounds, consisting in treating the readily soluble salts of 3.6-dismino l0-alkylacridinium cornpounds with tannin in the presence of acid-binding; agents.

2. As new substance the products obtained by treating the readily soluble salts of 3.6- lianiino-10-alkylacridiniuni-compoundswith tannin in the presence of acid-binding agents.

3. As new substance the product obtained by treating the readily soluble salts of 3.6- tliamino-lO-inethylacridiniuni with tannin in the presence of acid-binding agents, forniinga bright orangewcllow. colored powder, absolutely tasteless. suitable for lake colors, which in cold water dissolves extremely diiiicultly, whereas in hot water and alcohol the solubility is somewhat better.

In witness whereof I have hermnto signed my name this sixteenth day of dune, L92 in the presence of two subscribing witnesses.

n11. LOUIS signers.

Witnesses Fnrrz Swiss, Answer SGHWALB. 

